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Exhaustion is Associated With Low Macrophage Migration Inhibitory Factor Expression in Patients With Coronary Artery Disease

Martijn Kwaijtaal, MSc, André J. van der Ven, MD, PhD, Rob van Diest, PhD, Cathrien A. Bruggeman, PhD, Frits W. H. M. Bär, MD, PhD, Thierry Calandra, MD, PhD, Ad Appels, PhD and Fred C. G. J. Sweep, PhD

From the Department of Medical Microbiology, University Hospital Maastricht, Maastricht, The Netherlands (M.K., C.A.B.); the Departments of Internal Medicine (A.J.v.d.V.) and Chemical Endocrinology (F.C.G.J.S.), Radboud University Nijmegen Medical Center Nijmegen, Nijmegen, The Netherlands (A.J.v.d.V.); the Departments of Psychiatry and Neuropsychology (R.v.D.), Cardiology (F.W.H.M.B.), and Medical Psychology (A.A.), Maastricht University, Maastricht, The Netherlands; and the Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland (T.C.).


Figure 112
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  		Figure 1. Flow chart of patient selection and assessments. All three blood samples were collected of 172 patients.

 

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  		Figure 2. hsCRP, interleukin-1 receptor antagonist, interleukin-6, neopterin, and macrophage migration inhibitory factor concentrations in blood over 18 months of follow up after percutaneous coronary intervention. Boxes represent 50% of all samples and thick line in boxes is the median concentration. Bars represent 95% confidence intervals; nonparametric Friedman Rank test was used. N for all groups was 172.

 

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  		Figure 3. Macrophage migration inhibitory factor concentration in blood after 18 months in exhausted and nonexhausted patients. Total patient population is divided in exhausted versus nonexhausted based on 18-month exhaustion scores. White box represents the exhausted group; gray box represents the nonexhausted group. Bars represent 95% confidence intervals; boxes represent the 50% range of the variable and the thick line in the boxes is the median. Mann-Whitney U test was performed to test for differences between the two groups. N for the exhausted group was 92; N for the nonexhausted group was 89.

 




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