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Predictors of Premature Antidepressant Discontinuation in Functional Gastrointestinal Disorders

From the Division of Gastroenterology (G.S.S., J.E.E., R.E.C.) and the Department of Psychiatry (P.J.L., R.E.C.), Washington University School of Medicine, and the Department of Veterans Affairs Medical Center (P.J.L.), Saint Louis, Missouri.

View larger version (16K): [in this window] [in a new window]   Figure 1. Kaplan-Meier plots showing time to discontinuation of antidepressant therapy. Premature discontinuation (within the first 6 months after initiation) trended toward being more common in female subjects (p = .08 compared with males).

View larger version (20K): [in this window] [in a new window]   Figure 2. Kaplan-Meier plots showing time to discontinuation of antidepressant therapy in relation to degree of somatization on the state and trait measures. The somatization state measure was dichotomized into higher and lower degree of somatization for illustrative purposes here and in Figure 3. A higher degree of somatization by either measure predicted premature antidepressant discontinuation.

View larger version (20K): [in this window] [in a new window]   Figure 3. Kaplan-Meier plots showing the additive effect of a higher degree of somatization (state measure for these plots) and the presence of psychiatric comorbidity on premature antidepressant discontinuation. The effect of somatization on discontinuation is most pronounced in the first 2 months after antidepressant initiation.