Psychosomatic Medicine
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Published online before print September 10, 2007, 10.1097/PSY.0b013e31814b260d
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Treatment of Post-Myocardial Infarction Depressive Disorder: A Randomized, Placebo-Controlled Trial With Mirtazapine

Adriaan Honig, MD, PhD, Astrid M. G. Kuyper, MD, Aart H. Schene, MD, PhD, Joost P. van Melle, MD, PhD, Peter de Jonge, MD, PhD, Dorien M. Tulner, MD, Annique Schins, MD, PhD, Harry J. G. M. Crijns, MD, PhD, Petra M. J. C. Kuijpers, MD, PhD, Helen Vossen, MPsych, Richel Lousberg, PhD, Johan Ormel, PhD On behalf of the MIND-IT investigators*

From the Department of Psychiatry (A.M.G.K., A.H.S.), Academic Medical Center Amsterdam, Netherlands; Department of Cardiology (J.P.v.M.), Thoraxcenter, University Medical Center Groningen, Netherlands; Department of Internal Medicine and Psychiatry (P.d.J.), University Medical Center Groningen, Netherlands; Department of Psychiatry (D.T.), Medical Center Leeuwarden, Netherlands; Department of Psychiatry (A.S.), Academical Hospital Maastricht, Netherlands; Department of Cardiology (H.J.G.M.C., P.M.J.C.K.) and Psychiatry (H.V., R.L.), University Hospital Maastricht, Netherlands; and Department of Social Psychiatry and Psychiatric Epidemiology (J.O.), University Medical Center, Groningen, Netherlands.


Figure 13
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  		Figure 1. Flow chart of the intervention trial. CIDI = Composite International Diagnostic Overview; MI = myocardial infarction; RCT = randomized, controlled trial.

 

Figure 23
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  		Figure 2. Effects of mirtazapine versus placebo in post-myocardial infarction depressive disorder, measured with Hamilton-Depression Rating Scale (Ham-D 17) (entire treatment phase).

 

Figure 33
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  		Figure 3. Effects of mirtazapine versus placebo in post-myocardial infarction (MI) depressive disorder, measured with Beck Depression Inventory (BDI) (entire treatment phase).

 

Figure 43
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  		Figure 4. Weight curves mirtazapine versus placebo.

 




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