Psychosomatic Medicine
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Published online before print November 8, 2007, 10.1097/PSY.0b013e31815a8ba8
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Right arrow Stress and Coping

Combination of Caregiving Stress and Hormone Replacement Therapy is Associated With Prolonged Platelet Activation to Acute Stress Among Postmenopausal Women

Kirstin Aschbacher, MS, Roland von Känel, MD, Paul J. Mills, PhD, Suzi Hong, PhD, Susan K. Roepke, BA, Brent T. Mausbach, PhD, Thomas L. Patterson, PhD, Michael G. Ziegler, MD, Joel E. Dimsdale, MD, Sonia Ancoli-Israel, PhD and Igor Grant, MD

From the Department of Psychiatry (K.A., R.v.K., P.J.M., S.H., S.K.R., B.T.M., T.L.P., J.D., S.A.-I., I.G.), University of California, San Diego, San Diego, California; Department of General Internal Medicine (R.v.K.), University Hospital Bern, Switzerland; San Diego Veterans Affairs Healthcare System (T.L.P., S.A.-I., I.G.), La Jolla, California, USA; and Department of Medicine (M.G.Z.), University of California, San Diego, San Diego, California.


Figure 116
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  		Figure 1. The figures depict profiles of platelet activation over time in response to an acute speech stressor task. Caregivers (CG) taking hormone replacement therapy (HRT) exhibited significant increases in platelet P-selectin expression and prolonged fibrinogen receptor expression in recovery. Non-caregivers taking HRT exhibited significant declines in the percentage of platelet aggregates at recovery ralative to CG taking HRT.

 

Figure 216
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  		Figure 2. The figures depict profiles of platelet activation over time in response to an acute speech stressor task. Caregivers (CG) taking hormone replacement therapy (HRT) exhibited significant increases in platelet P-selectin expression and prolonged fibrinogen receptor expression in recovery. Non-caregivers taking HRT exhibited significant declines in the percentage of platelet aggregates at recovery ralative to CG taking HRT.

 

Figure 316
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  		Figure 3. The figures depict profiles of platelet activation over time in response to an acute speech stressor task. Caregivers (CG) taking hormone replacement therapy (HRT) exhibited significant increases in platelet P-selectin expression and prolonged fibrinogen receptor expression in recovery. Non-caregivers taking HRT exhibited significant declines in the percentage of platelet aggregates at recovery ralative to CG taking HRT.

 




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