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fMRI in Patients With Motor Conversion Symptoms and Controls With Simulated Weakness

From the Division of Clinical Neurosciences (J.S., A.Z.), School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK; Division of Psychiatry (E.S., M.S.), School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh, UK; Department of Neuropsychology (M.M.), Institute for Psychology, University of Zurich, Zurich, Switzerland; Division of Psychological Medicine (R.A.), Institute of Psychological Medicine, Institute of Psychiatry, King’s College, London, UK; Department of Theoretical and Applied Linguistics (S.F.), School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, UK.

View larger version (73K): [in this window] [in a new window]   Figure 1. Corrected group analysis of task. Cases with conversion disorder versus controls simulating weakness. Images have been flipped to correspond with weakness of the RIGHT ankle. Activations in RED = areas more active when moving the right leg relative to the left. Activations in BLUE = areas more active when moving the left leg relative to the right. The left hemisphere is on the right of each image. Thresholded at p < .05, corrected, k = 0. The images have been corrected for multiple comparisons. Significance is indicated by the t-score bars.

View larger version (75K): [in this window] [in a new window]   Figure 2. Uncorrected group analysis of task. Cases with conversion disorder versus controls simulating weakness. Images have been flipped to correspond with weakness of the RIGHT ankle. Activations in RED = areas more active when moving the right leg relative to the left. Activations in BLUE = areas more active when moving the left leg relative to the right. The left hemisphere is on the right of each image. Thresholded at p < .001, uncorrected, k = 100. Significance is indicated by the t-score bars.