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Psychosocial Influences on HIV-1 Disease Progression: Neural, Endocrine, and Virologic Mechanisms

From the Department of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, the Norman Cousins Center, Jonsson Comprehensive Cancer Center, UCLA AIDS Institute, and UCLA Molecular Biology Institute, Los Angeles California.

View larger version (13K): [in this window] [in a new window]   Figure 1. Theoretical model of biobehavioral influences on HIV-1 disease progression. Psychosocial factors = stress, depression, coping, social support, temperament, and other CNS-mediated influences on neural and endocrine activity, (A) CNS-mediated effects of psychosocial factors on neural/endocrine activity, (B) neural/endocrine influences on HIV-1 replication, (C) effects of HIV-1 replication on clinical disease progression.

View larger version (12K): [in this window] [in a new window]   Figure 2. Theoretical model of SNS mediation of psychosocial influences on HIV-1 disease progression. SNS = sympathetic nervous system, IFN = Type I interferon. CCR5 and CXCR4 = cell surface expression of cellular coreceptors that complement CD4 as mediators of HIV-1 infection.