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Fig. 2. Circadian rhythms in the 5-HT and norepinephrine-dopamine systems in the rat brain. Frequency of occurrence of peak time as shown in the cited reports. The black bar corresponds to the dark period. Numbers at bottom represent hours after beginning the light (L) or dark (D) period. A, 5-HT system: 5-HT (•), 5-HIAA ( ${circ}$ ), and tryptophan hydroxylase ( ${blacksquare}$ ). B, Norepinephrine-dopamine system: norepinephrine ( ${circ}$ ), dopamine ( ${square}$ ), ${alpha}$ -adrenoceptor (•), and ß-adrenoceptor ( ${blacksquare}$ ).

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