Fig. 5. Photomicrograph illustrating the induction of NGFI-ß mRNA molecules in the PVh of the hypothalamus by cocaethylene (cocaeth). Top, Schematic coronal view depicting the topographical organization of the PVh with an emphasis on parvocellular neurosecretory neurons. Middle, Photomicrograph through a common level of the PVh of a rat injected with NaCl. Hybridized neurons are rare in parvocellular aspects of this hypothalamic nucleus. Bottom, Representative photomicrograph of the PVh of a rat injected with cocaethylene. A reliable increase in the number of positively hybridized neurons in the parvocellular (and magnocellular) aspects of the PVh is apparent 30 minutes after cocaethylene treatment. * = third ventricle; pv = periventricular. Reprinted with permission from Ref. 159.
