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Fig. 1. Steroid metabolic pathway. DHEA = dehydroepiandrosterone; DHEA-S = dehydroepiandrosterone sulfate; HSD = hydroxysteroid dehydrogenase; SCC = side-chain cleavage; SST = steroid sulfotransferase; 1 = site of blockade by ketoconazole; 2 = site of blockade by metyrapone; 3 = site of blockade by aminoglutethimide.





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