Fig. 2. Times courses of physiological, endocrine parameters after endotoxin (0.4 ng/kg), or placebo injection during the initial slow wave sleep episode or the same time in sleep-deprived subjects (N = 10). Depicted are means ± SEMs. Left panels, time courses after injection of endotoxin (•) compared with placebo (
in sleeping subjects. Repeated measure analyses revealed significant group (endotoxin vs. placebo) or time by group effects for rectal temperature, heart rate, and cortisol plasma levels. Middle panels, time courses after injection of endotoxin (
) compared with placebo (
) in sleep-deprived subjects. Repeated measure analyses revealed significant group (endotoxin vs. placebo) or time by group effects for rectal temperature, heart rate, and cortisol plasma levels. Right panels, time courses of difference values (endotoxin minus placebo) in sleeping subjects (
) compared with sleep-deprived subjects (
). Repeated measure analyses revealed no significant group (sleep vs. sleep deprivation) or group by time effects for any parameter tested. * p < .05 for time point differences (simple contrasts).
