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Fig. 1. Diurnal variations in measures of coagulation and fibrinolysis in exhausted individuals (
) and controls (
). Data represent mean ± SEM. The coagulation measures F1+2, TAT, and VII:a and all fibrinolytic measures displayed significant diurnal variations (all p values < .01). Exhausted individuals, however, had significantly higher levels of tPA:ag, PAI-1:act, and tPA-PAI:ag at 7:00 AM (all p values < .04), whereas these levels were similar to those of controls at 6:00 PM (all p values > .10). This indicates a more pronounced diurnal variation in VE with respect to fibrinolytic measures. A similar, more pronounced diurnal variation in VE with respect to coagulation measures was absent (all p values > .10). Significantly higher levels of F1+2 and FNG were found in VE both at 7:00 AM and at 6:00 PM (p = .02), and a similar trend was found for VII:c (p = .07). No significant group differences were found in TAT, VII:a, VIII:c, and vWf:ag (all p values > .10).
