Fig. 1. Design of the study. *Gastrointestinal cancer patients with known metastatic disease at the time of diagnosis were only randomized between IS and SC. °Erroneous diagnosis (N = 2), delay of more than 3 months from diagnosis to inclusion (N = 1), and dementia (N = 1). Patients who were under medical investigation for a suspected breast cancer were informed that GR would be an option only if surgery confirmed a cancer diagnosis.

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