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Figure 4. Colonic balloon volumes (mean ± SEM) in the fasting state (before lipids) and during the first (0 to 30 minutes) and second (30 to 60 minutes) half-hour of duodenal lipid infusion before the treatment period (baseline; A) and after treatment (B). The balloon volumes reflect colonic tone, and significant reductions in the balloon volumes during the lipid infusion compared with before are seen in both groups, as an indicator of increased tone at baseline (A). However, after the treatment period (B), significant reductions in the balloon volumes during the lipid infusion compared with before are seen only in the control group, indicating increased tone, whereas no colonic tone response to the duodenal lipids is seen in the hypnotherapy group. Moreover, the balloon volumes before lipids are significantly lower in the hypnotherapy group than in the control group after treatment (p < .05; B), whereas no differences are seen at baseline (A).