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Figure 3. Effect of stress on airway reactivity measured in ovalbumin (OVA)-sensitized and airway-challenged BALB/c mice. The frequency that caused 50% of maximal contraction (ES50) was calculated. Mean ES50 from the nonstressed group I was set as 100%. Airway reactivity was higher in stressed mice treated with phosphate-buffered saline (PBS) compared with nonstressed mice, #p = .024. Application of neurokinin-1 receptor antagonist (NK-1-RA) in stressed mice significantly abrogated the stress-induced increase. *p < .017. Indicated are mean and SEM from 7 to 9 mice per group.
