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Figure 1. Mechanism of penile erection and the nitric oxide/cyclic guanosine monophosphate-enhancing effect of phosphodiesterase type 5 isoenzyme inhibitors. NANC = nonadrenergic-noncholinergic neurons; NO = nitric oxide; cGMP = cyclic guanosine monophosphate; PDE5 = phosphodiesterase type 5. (Adapted from Sadovsky R, Miller T, Moskowitz M, Hackett G. Three-year update of sildenafil citrate [Viagra®] efficacy and safety. Int J Clin Pract 2001;55:115–128.)





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