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Figure 5. Plasma hormone levels (mean ± standard error) in drug vehicle- (V) and chemotherapy- (C) treated mice at 0, 1, and 5 days after drug vehicle or chemotherapy administration. Significance symbols: treatment (•), group (*), and day (
). (A) Corticosterone (CORT): at day 0 (1 day after experimental housing condition formation), CORT levels were significantly higher for IG mice than in mice in all other housing conditions (p values <.05; *). Also, CORT levels at day 0 were significantly higher than those at 1 and 5 days in V-IG mice and higher than those at 5 days in C-IG mice (p values <.05; ). Accordingly, CORT levels at 1 day were significantly higher for C-IG than for V-IG mice (p < .01; •). (B) Growth hormone (GH): at day 0, GH levels were significantly higher for GI mice than in mice in all other housing conditions (p values <.01;*) as well as for II than for IG mice (p < .05; *). Also at day 0, GH levels in GI mice were significantly higher than those at 1 or 5 days (p values <.05; ). GH levels at 5 days were significantly higher in C-GI mice than in C-IG mice (p < .05; *). Also, GH levels at 5 days were significantly higher for C-GI than for V-GI mice (p < .05; •). (C) Testosterone (T): for V mice, T levels, overall, were significantly higher in GI than in II mice (p = .01; *) and marginally higher in GI than in IG and GG mice (p = .060 and p = .086, respectively). T levels did not differ significantly for C mice or between the C and V conditions.
