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Figure 1. Frailty and the risk of Alzheimer’s disease (AD). A. Baseline frailty. This figure shows the cumulative hazard of AD during the study for two participants: The first has low baseline frailty, i.e., better performance, measured at baseline (solid line; 10th percentile: –0.75 frailty units) and a second with high baseline frailty, i.e., poorer performance (dotted line; 90th percentile: 0.68 frailty units), adjusted for age, gender, and education. B. Annual rate of change in frailty. This figure shows the cumulative hazard of AD during the study for two participants: The first has a mildly decreasing rate of change in frailty, i.e., improving performance (solid line; 10th percentile: –0.20 frailty units/year) and a second with a rapidly increasing rate of change in frailty, i.e., deteriorating performance (dotted line; 90th percentile: 0.39 frailty units/year), adjusted for age, gender, education, and baseline frailty.
